The Scientific Evidence behind the use of N-acetylcarnosine Eyedrops

It’s all well and good stating that a product works, but what is really important is that statements such as these are backed up with scientific research that has been carried out using the most rigorous study protocols. Cataracts Drops meet this strict criterium.

The leading research in this area was carried out by Dr Mark Babizhayev and his team from the Moscow Helmholtz Research Institute of Eye Diseases. The researchers specifically examined the use of the ophthalmic formulation of N-acetylcarnosine (as found in Can-C Eyedrops) in cataract patients in order to establish whether or not using N-acetylcarnosine in such a way could actually obviate the need for these patients to undergo cataract surgery. The results were truly remarkable.

Dr Babizhayev and his colleagues established a controlled clinical trial that involved 110 eyes. The eyes were split into three groups:

• 60 eyes received the N-acetylcarnosine eye drop treatment twice a day
• 30 eyes formed a control group & were administered with a placebo eye drop
• 20 eyes received no treatment whatsoever

All of the eyes were evaluated at the start of the study and then at 2 monthly intervals over a total period of 6 months. Incredibly, at the end of the 6 month trial period a staggering 96% of the treated eyes showed improvement. But even more exciting was the fact that those eyes that showed the greatest improvements were in those affected by the most common form of cataracts - age related cataracts (often referred to as senile cataract).

To understand just how incredible these results were, you have to put them into some sort of context. Up until this point, it had been thought that the only way to effectively treat cataracts was by surgery. No non-invasive treatments were available. The clinical trial results confirmed that at last there really was an effective, alternative, non-surgical option available for the treatments of cataracts.

The study also revealed a remarkable new phenomenon - the "melting snow" effect. This was the name given to the clearly visible breakdown of the damaged proteins that cause cataracts - even after only 1 month of treatment. The reversal process began at the periphery with the affected lenses which gradually became more and more transparent. As the growth of the cataracts was reversed, so vision improved.

Dr Babizhayev is now the guiding light behind Innovative Vision Products Inc which has patented and approved the N-acetylcarnosine formulation found in Can-C Eyedrops.

Resources -  The Scientific Evidence behind the use of N-acetylcarnosine Eyedrops

Cataracts and Glycation

                         Image via WikipCataracts form in the lens of the eye - a biconvex structure that is essentially made up of water and proteins. These proteins are arranged in a very specific way that enables the lens to be kept clear and light to pass through it. However, if the proteins become damaged a cataract may start to form. And it is a process known as glycation that is a major culprit when it comes to protein damage.

Glycation is the reaction that occurs when simple sugar molecules such as fructose and glucose become attached (bind) to proteins (or lipid fats) without the controlling action of an enzyme. This process, also called non-enzymatic glycosylation, results in the formation of rogue molecules known as advanced glycation endproducts (AGEs). These AGEs interact with adjacent proteins (cross link) which results in impaired function, free radical formation and accelerated aging. AGEs are therefore linked to many age-related diseases and conditions including the development of senile cataracts.

Glycation is of particular concern to diabetics who already suffer from the effects of poor glucose control. Certainly, being diabetic increases your chances of developing cataracts due to increased glycation occurring.

It stands to reason then that if you can prevent and reverse glycation you are well on the way to helping to prevent and reverse cataracts. Fortunately, a chemical compound known as carnosine is capable of doing just that. Carnosine is a di-peptide made up from a combination of the amino-acids beta-alanine and l-histadine and has proven to be a very effective inhibitor of glycation. It works by competing with proteins for binding sites on sugar molecules. It is also thought to bind already produced AGEs so they get removed. In this way carnosine is capable of effectively preventing and reversing the development and growth of cataracts.

The trick has been to get carnosine to where it is needed most. And this where Can-C Eyedrops come in to play. The carnosine found in Can-C Eyedrops´ unique formula is specifically in the form of N-acetylcarnosine. N-acetylcarnosine acts as a "carrier" of carnosine which means that it can be delivered directly into the aqueous humor of the eye (the fluid surrounding the lens). N-acetylcarnosine is also highly resistant to the enzyme carnosinase - the natural enemy of carnosine because its action is to break down carnosine.

And the scientific evidence is clear. Clinical trials showed that after 6 months use of cataract eye drops 90% of patients had improved vision as the carnosine drops gently and effectively melted away their cataracts. 

Resource - Cataracts and Glycation